Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease
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چکیده
منابع مشابه
Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease
The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been the mainstream concept underlying AD research for over 20 years. However, all attempts to develop Aβ-targeting drugs to treat AD have ended in failure. Here, we review recent findings indicating that the main factor u...
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The cholinergic deficit in Alzheimer’s disease (AD) remains the cornerstone for the understanding of chemical signal transfer. Hypofunctions of cholinergic systems are significantly involved in the signs and symptoms of senile dementia of the Alzheimer type. Cognitive deficits in AD have been widely associated with dysfunction of the cholinergic system. As a diagnostic marker of AD the activity...
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Spirochetes, biofilms, and innate immune system activity have all been recently found in the brains of Alzheimer’s disease patients. The mechanism and actions of those factors in producing the disease were discussed in those studies. However, neither the production nor the role of beta amyloid was included in the discussion of those studies. In this commentary, we hypothesize how the developmen...
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This chapter reviews the major hypotheses in Alzheimer’s disease (AD) research with the focus on amyloid hypothsis. Since amyloid hypothesis of AD pathology was proposed, extracellular amyloid β (Aβ) toxicity and its role of inducing synaptic plasticity and memory function has been studying intensively. Accumulating evidence indicates that Aβ also exists inside the neurons in AD. Intracellular ...
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The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis.
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2018
ISSN: 1662-453X
DOI: 10.3389/fnins.2018.00025